teresina laragione baylor college of medicine email

TERESINA LARAGIONE BAYLOR COLLEGE OF MEDICINE EMAIL UPDATE

Pipettes were brought in contact with a cell using a micromanipulator to form a. These new discoveries should provide the basis for the development of new drugs targeting Trpv2 to better preserve joint architecture and improve outcome in RA. Baylor College of Medicine, Houston, Texas.

TERESINA LARAGIONE BAYLOR COLLEGE OF MEDICINE EMAIL UPDATE

O-1821 was then used to treat KRN serum-induced arthritis in C57BL/6 mice and it significantly reduced arthritis severity scores and preserved a nearly normal joint histology.Ĭonclusion: We have identified a new regulator of arthritis severity and joint damage in vivo, and show that at least part of Trpv2 activity involves suppression of the invasive properties of FLS both in rodents and patients with RA. Are you looking for Baylor College Of Medicine Email Portal login page If you are interested in Baylor College Of Medicine Email Portal login page then let me quickly update you that here in this page you are currently reading is Baylor College Of Medicine Email Portal login url. 46 West Springfield Co-operative Bank 48 Western Massachusetts Association of Credit Executives Inc Front Cover Western New England College opp inside Back.

O‑1821 significantly reduced invasion by as much as 90% (p<0.01). Teresina Laragione Icahn School of Medicine at Mount Sinai Ali Mobasheri University of Oulu Ildiko Szabo University of Padova Current institution Baylor College of Medicine Houston, United States. We next used the Trpv2-specific agonist O-1821 to treat FLS from DA rats and RA patients. Results: Knock-down of Trpv2 with siRNA unexpectedly significantly increased FLS invasion by nearly 4-fold suggesting that this gene is a suppressor of invasion. Works: 14 works in 16 publications in 2 languages and 29 library holdings Roles: Other, Contributor, Author: Publication Timeline. After the onset of arthritis animals were assigned to receive either O‑1821 or control vehicle BID. For the in vivo studies, C57BL/6 mice received KRN serum intra-peritoneal to induce arthritis. Methods: Trpv2 was knocked-down using siRNA, or was stimulated with the specific agonist O-1821, and its role in FLS invasion determined in Matrigel invasion assays over 24 hours. In this study we characterize the role of this ion channel in arthritis. We have identified significantly increased levels of the non-selective cation channel Trpv2 (transient receptor potential vanilloid subfamily, type 2 channel) in highly invasive FLS obtained from arthritis-susceptible DA rats. Gulko, 5 and Christine Beeton 1, 6 Mark R. The FLS in vitro invasive properties through Matrigel correlate with disease severity and joint damage in rodents and patients with RA, yet, little is known about the genes regulating RA severity, FLS invasion and joint damage. Chauhan, 3 Teresina Laragione, 5 Prcio S.

The fibroblast-like synoviocyte (FLS) has a central role in the formation of synovial hyperplasia and in articular damage. Disease remission is still rarely achieved and better treatments are needed.

Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic disease associated with increased risk of developing disability.

Teresina laragione baylor college of medicine email